![]() ![]() Lysosomes, the major degradative compartments of the cell acquire unique properties upon receiving external signals. With this review, we aim to stimulate an increase in the quantity and quality of research on lysosomes and further groundābreaking discoveries on an organelle that continues to surprise and excite cell biologists. To extract accurate information and avoid misinterpretations, we discuss the best strategies to identify lysosomes and assess their characteristics and functions. ![]() We highlight the principles behind these methods, the methodological strategies, and their advantages and limitations. In this review, we cover current methods used to analyse lysosome morphology, positioning, motility, and function. ![]() Methodological advances played a key part in generating our current knowledge about the biology of this multifaceted organelle. Lysosomes were regarded as exclusively degradative organelles, but more recent research has revealed that they play essential roles in several other cellular functions, such as nutrient sensing, intracellular signalling, and metabolism. Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles.
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